Molecular Genetics and Epidemiology of Vitiligo

The genetics and epidemiology of generalized vitiligo

vitiligo Generalized vitiligo (GV) is the most common depigmentation disorder, in which acquired multifocal patches of white skin and overlying hair result from loss of melanocytes in the involved areas (Figure 1) [1,2]. Th e prevalence of GV is approximately 0.5% in various populations [3], with an average age of onset at about 24 years and occurring with approximately equal frequency in males...

Pneumoviruses: Molecular Genetics and Reverse Genetics

Pneumoviruses are responsible for significant respiratory disease in their hosts and represent a major problemfor human and animal health. Pneumoviruses are members of the family Paramyxoviridae, subfamilyPneumovirinae and the virus particles consist of a negative-sense, nonsegmented RNA genome within a helical nucleocapsid structure enveloped in a lipid membrane derived from the ho...

Molecular genetics and epidemiology of prostate carcinoma.

Current aspects of vitiligo genetics

Vitiligo is a common acquired depigmentation disorder of the skin manifested by the presence of white macules. The disease occurs at a frequency of approximately 1-4% of the world population. Currently, the most popular theory of vitiligo development is a multifactorial hypothesis according to which genetic conditions predispose vitiligo macules to occur as a result of specific environmental fa...

Charcot–Marie–Tooth disease: Genetics, epidemiology and complications

Background and aims: Charcot Marie Tooth disease (CMT) is the most prevalent hereditary neuropathy and its frequency is 1 in 2500. CMT is a heterogeneous disease and has different clinical symptoms. The prevalence of CMT and involved genes differ in different countries. CMT patients experience considerable sleep problems and a higher risk of decreased quality of life. In this w...

Genetic Epidemiology and Heritability of Vitiligo

1.1 Prevalence & incidence The population prevalence of vitiligo ranges from 0.1% to 2% and shows a wide variability among ethnic groups (Bolognia et al., 1998; Hann and Nordlund, 2000). Whereas the estimated population prevalence of vitiligo is approximately 0.38% for Caucasians in the United States and Northern Europe (Howitz et al., 1977), vitiligo affects 0.19% of the population in China (X...